Non-Syndromic Hearing Impairment Protein 5 (GSDME) (AA 1-152) antibody

Catalog No. ABIN7113358

This Rabbit Polyclonal antibody specifically detects in ELISA, WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Non-Syndromic Hearing Impairment Protein 5 (GSDME) (AA 1-152) antibody (ABIN7113358)

Target: Non-Syndromic Hearing Impairment Protein 5 (GSDME)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details

Binding Specificity: AA 1-152

Purpose: GSDME antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-152aa

Immunogen: deafness, autosomal dominant 5

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details

Target: Non-Syndromic Hearing Impairment Protein 5 (GSDME)

Alternative Name: GSDME

Background:

Synonyms: Gasdermin-E|Inversely correlated with estrogen receptor expression 1 (ICERE-1)|Non-syndromic hearing impairment protein 5|Gasdermin-E, N-terminal (GSDME-NT)|Gasdermin-E, C-terminal (GSDME-CT)|GSDME|DFNA5|ICERE1

Background: Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene.

Molecular Weight: 54 kDa

Gene ID: 1687

UniProt: O60443