FLNB antibody

Catalog No. ABIN7114241

The Rabbit Polyclonal anti-FLNB antibody has been validated for WB, IHC and ELISA. It is suitable to detect FLNB in samples from Human, Mouse and Rat.

Quick Overview for FLNB antibody (ABIN7114241)

Target: FLNB (Filamin B, beta (FLNB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLNB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-FLNB Antibody

Purpose: FLNB antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: filamin B, beta (actin binding protein 278)

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:1000, IHC: 1:20 - 1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for FLNB

Target: FLNB (Filamin B, beta (FLNB))

Alternative Name: FLNB

Background:

Synonyms: Filamin-B (FLN-B)|ABP-278|ABP-280 homolog|Actin-binding-like protein|Beta-filamin|Filamin homolog 1 (Fh1)|Filamin-3|Thyroid autoantigen|Truncated actin-binding protein (Truncated ABP)|FLNB|FLN1L|FLN3|TABP|TAP

Background: This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3, boomerang dysplasia, autosomal dominant Larsen syndrome, and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Molecular Weight: 298 kDa

Gene ID: 2317

UniProt: O75369

Pathways: Maintenance of Protein Location