GAR1 antibody

Catalog No. ABIN7114489

This Rabbit Polyclonal antibody specifically detects GAR1 in ELISA, WB, IHC, IF and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GAR1 antibody (ABIN7114489)

Target: GAR1 (GAR1 Ribonucleoprotein Homolog (Yeast) (GAR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAR1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-GAR1 Antibody

Purpose: GAR1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: GAR1 ribonucleoprotein homolog(yeast)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for GAR1

Target: GAR1 (GAR1 Ribonucleoprotein Homolog (Yeast) (GAR1))

Alternative Name: GAR1

Background:

Synonyms: H/ACA ribonucleoprotein complex subunit 1|Nucleolar protein family A member 1|snoRNP protein GAR1|GAR1|NOLA1

Background: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein(H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase(TERT) holoenzyme.

Molecular Weight: 28 kDa

Gene ID: 54433

UniProt: Q9NY12