GEMIN6 antibody

Catalog No. ABIN7114528

This Rabbit Polyclonal antibody specifically detects GEMIN6 in WB and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for GEMIN6 antibody (ABIN7114528)

Target: GEMIN6 (Gem (Nuclear Organelle) Associated Protein 6 (GEMIN6))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GEMIN6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GEMIN6 Antibody

Purpose: GEMIN6 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: gem(nuclear organelle) associated protein 6

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for GEMIN6

Target: GEMIN6 (Gem (Nuclear Organelle) Associated Protein 6 (GEMIN6))

Alternative Name: GEMIN6

Background:

Synonyms: Gem-associated protein 6 (Gemin-6)|SIP2|GEMIN6

Background: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins(snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Molecular Weight: 19 kDa

Gene ID: 79833

UniProt: Q8WXD5

Pathways: Ribonucleoprotein Complex Subunit Organization