Glutaredoxin 2 antibody

Catalog No. ABIN7114635

This anti-Glutaredoxin 2 antibody is a Rabbit Polyclonal antibody detecting Glutaredoxin 2 in WB and ELISA. Suitable for Human, Rat and Mouse.

Quick Overview for Glutaredoxin 2 antibody (ABIN7114635)

Target: Glutaredoxin 2 (GRX2)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutaredoxin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Glutaredoxin 2 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: glutaredoxin 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for Glutaredoxin 2

Target: Glutaredoxin 2 (GRX2)

Alternative Name: GLRX2

Background: Synonyms:GRX2 Background:Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione(GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Molecular Weight: 16 kDa

Gene ID: 51022

UniProt: Q9NS18

Pathways: Cell RedoxHomeostasis