HOMER1 antibody

Catalog No. ABIN7115100

This anti-HOMER1 antibody is a Rabbit Polyclonal antibody detecting HOMER1 in WB, ELISA, IHC, IP and FACS. Suitable for Human and Mouse.

Quick Overview for HOMER1 antibody (ABIN7115100)

Target: HOMER1 (Homer Homolog 1 (HOMER1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOMER1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS)

Product Details anti-HOMER1 Antibody

Purpose: HOMER1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: homer homolog 1(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for HOMER1

Target: HOMER1 (Homer Homolog 1 (HOMER1))

Alternative Name: HOMER1

Background:

Synonyms: Homer protein homolog 1 (Homer-1)|HOMER1|SYN47

Background: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

Molecular Weight: 46-48 kDa

Gene ID: 9456

UniProt: Q86YM7

Pathways: Skeletal Muscle Fiber Development