MAP4K6 antibody (AA 1-304)

Catalog No. ABIN7116324

This anti-MAP4K6 antibody is a Rabbit Polyclonal antibody detecting MAP4K6 in WB, ELISA and IHC. Suitable for Human, Mouse and Rat.

Quick Overview for MAP4K6 antibody (AA 1-304) (ABIN7116324)

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP4K6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MAP4K6 Antibody

Binding Specificity: AA 1-304

Purpose: MINK1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-304aa

Immunogen: misshapen-like kinase 1(zebrafish)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MAP4K6

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Alternative Name: MINK1

Background:

Synonyms: Misshapen-like kinase 1|GCK family kinase MiNK|MAPK/ERK kinase kinase kinase 6 (MEK kinase kinase 6, MEKKK 6)|Misshapen/NIK-related kinase|Mitogen-activated protein kinase kinase kinase kinase 6|MINK1|B55|MAP4K6|MINK|YSK2|ZC3

Background: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Molecular Weight: 150 kDa

Gene ID: 50488

UniProt: Q8N4C8

Pathways: Synaptic Membrane