OSBPL3 antibody (AA 370-520)

Catalog No. ABIN7117176

This anti-OSBPL3 antibody is a Rabbit Polyclonal antibody detecting OSBPL3 in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for OSBPL3 antibody (AA 370-520) (ABIN7117176)

Target: OSBPL3 (Oxysterol Binding Protein-Like 3 (OSBPL3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OSBPL3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-OSBPL3 Antibody

Binding Specificity: AA 370-520

Purpose: OSBPL3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 370-520aa

Immunogen: oxysterol binding protein-like 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for OSBPL3

Target: OSBPL3 (Oxysterol Binding Protein-Like 3 (OSBPL3))

Alternative Name: OSBPL3

Background:

Synonyms: Oxysterol-binding protein-related protein 3 (ORP-3, OSBP-related protein 3)|OSBPL3|KIAA0704|ORP3|OSBP3

Background: Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum(ER) membranes(PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments(PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1(ITGB1) activation at the cell surface(PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology(PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion(PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3(PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol(PubMed:17428193).

Molecular Weight: 101 kDa

Gene ID: 26031

UniProt: Q9H4L5