TENT4B (AA 400-465) antibody
Quick Overview for TENT4B (AA 400-465) antibody (ABIN7117222)
Target
Reactivity
Host
Clonality
Application
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Binding Specificity
- AA 400-465
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Purpose
- TENT4B antibody
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Purification
- Immunogen affinity purified
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Purity
- ≥95 % as determined by SDS-PAGE
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Immunogen
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Immunogen sequence: 400-465aa
Immunogen: PAP associated domain containing 5
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Isotype
- IgG
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Application Notes
- WB: 1:500 - 1:2000
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freeze / thaw cycles.
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Storage
- -20 °C
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Storage Comment
- -20°C for 12 months
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Expiry Date
- 12 months
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- TENT4B
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Background
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Synonyms: Terminal nucleotidyltransferase 4B|Non-canonical poly(A) RNA polymerase PAPD5|PAP-associated domain-containing protein 5|Terminal guanylyltransferase|Terminal uridylyltransferase 3 (TUTase 3)|Topoisomerase-related function protein 4-2 (TRF4-2)|TENT4B|GLD4|PAPD5|TRF4-2|TUT3
Background: Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity(in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.
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Molecular Weight
- 50 kDa, 80 kDa
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Gene ID
- 64282
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UniProt
- Q8NDF8
Target
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