PDE9A antibody

Catalog No. ABIN7117437

The Rabbit Polyclonal anti-PDE9A antibody (ABIN7117437) specifically detects PDE9A in ELISA, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PDE9A antibody (ABIN7117437)

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE9A antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PDE9A Antibody

Purpose: PDE9A antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: phosphodiesterase 9A

Isotype: IgG

Application Details

Application Notes: IHC: 1:100-1:200, IF: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PDE9A

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Alternative Name: PDE9A

Background:

Synonyms: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A|PDE9A

Background: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP(PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart(PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein(Probable). In brain, involved in cognitive function, such as learning and long-term memory(By similarity).

Gene ID: 5152

UniProt: O76083