RFX3 antibody

Catalog No. ABIN7118388

This anti-RFX3 antibody is a Rabbit Polyclonal antibody detecting RFX3 in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for RFX3 antibody (ABIN7118388)

Target: RFX3 (Regulatory Factor X 3 (RFX3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFX3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RFX3 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: regulatory factor X, 3(influences HLA class II expression)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for RFX3

Target: RFX3 (Regulatory Factor X 3 (RFX3))

Alternative Name: RFX3

Background: Synonyms: Background:Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly(DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility(DNAH11, DNAH9 and DNAH5)(By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP(polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes(PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells(PubMed:12411430).

Molecular Weight: 70-79 kDa

Gene ID: 5991

UniProt: P48380