RHBDD1 antibody

Catalog No. ABIN7118505

This anti-RHBDD1 antibody is a Rabbit Polyclonal antibody detecting RHBDD1 in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for RHBDD1 antibody (ABIN7118505)

Target: RHBDD1 (Rhomboid Domain Containing 1 (RHBDD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RHBDD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RHBDD1 Antibody

Purpose: RHBDD1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: rhomboid domain containing 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RHBDD1

Target: RHBDD1 (Rhomboid Domain Containing 1 (RHBDD1))

Alternative Name: RHBDD1

Background:

Synonyms: Rhomboid-related protein 4 (RRP4)|Rhomboid domain-containing protein 1|Rhomboid-like protein 4|RHBDD1|RHBDL4

Background: Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation(ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum(ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion, inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis, modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis, inhibits apoptotic activity in spermatogonia.

Molecular Weight: 36 kDa

Gene ID: 84236

UniProt: Q8TEB9