SH3PXD2A antibody (AA 385-533)

Catalog No. ABIN7119018

This anti-SH3PXD2A antibody is a Rabbit Polyclonal antibody detecting SH3PXD2A in WB, ELISA, IHC and IF. Suitable for Human, Rat and Mouse.

Quick Overview for SH3PXD2A antibody (AA 385-533) (ABIN7119018)

Target: SH3PXD2A (SH3 and PX Domains 2A (SH3PXD2A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH3PXD2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SH3PXD2A Antibody

Binding Specificity: AA 385-533

Purpose: SH3PXD2A antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 385-533aa

Immunogen: SH3 and PX domains 2A

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SH3PXD2A

Target: SH3PXD2A (SH3 and PX Domains 2A (SH3PXD2A))

Alternative Name: SH3PXD2A

Background:

Synonyms: SH3 and PX domain-containing protein 2A|Adapter protein TKS5|Five SH3 domain-containing protein|SH3 multiple domains protein 1|Tyrosine kinase substrate with five SH3 domains|SH3PXD2A|FISH|KIAA0418|SH3MD1|TKS5

Background: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases(ADAMs), NADPH oxidases(NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1-or NOX3-dependent reactive oxygen species(ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.

Molecular Weight: 140 kDa

Gene ID: 9644

UniProt: Q5TCZ1