SIRT6 antibody (AA 1-192)

Catalog No. ABIN7119114

This anti-SIRT6 antibody is a Rabbit Polyclonal antibody detecting SIRT6 in WB, IHC and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for SIRT6 antibody (AA 1-192) (ABIN7119114)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-SIRT6 Antibody

Binding Specificity: AA 1-192

Purpose: SIRT6 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-192aa

Immunogen: sirtuin(silent mating type information regulation 2 homolog) 6

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IHC: 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Alternative Name: SIRT6

Background:

Synonyms: NAD-dependent protein deacylase sirtuin-6|NAD-dependent protein deacetylase sirtuin-6|Protein mono-ADP-ribosyltransferase sirtuin-6|Regulatory protein SIR2 homolog 6 (hSIRT6)|SIR2-like protein 6|SIRT6|SIR2L6

Background: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span(By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Molecular Weight: 49 kDa

Gene ID: 23408

UniProt: Q8N6T7