SPATA13 antibody

Catalog No. ABIN7119403

This Rabbit Polyclonal antibody specifically detects SPATA13 in WB, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SPATA13 antibody (ABIN7119403)

Target: SPATA13 (Spermatogenesis Associated 13 (SPATA13))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPATA13 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-SPATA13 Antibody

Purpose: SPATA13 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: spermatogenesis associated 13

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SPATA13

Target: SPATA13 (Spermatogenesis Associated 13 (SPATA13))

Alternative Name: SPATA13

Background:

Synonyms: Spermatogenesis-associated protein 13|APC-stimulated guanine nucleotide exchange factor 2 (Asef2)|SPATA13

Background: Acts as guanine nucleotide exchange factor(GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Molecular Weight: 75 kDa

Gene ID: 221178

UniProt: Q96N96