SS18L1 antibody (AA 47-396)

Catalog No. ABIN7119693

This anti-SS18L1 antibody is a Mouse Monoclonal antibody detecting SS18L1 in WB and ELISA. Suitable for Human, Mouse and Rat.

Quick Overview for SS18L1 antibody (AA 47-396) (ABIN7119693)

Target: SS18L1 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1 (SS18L1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This SS18L1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 7A7

Product Details anti-SS18L1 Antibody

Binding Specificity: AA 47-396

Purpose: SS18L1 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 47-396aa

Immunogen: synovial sarcoma translocation gene on chromosome 18-like 1

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000-1:6000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SS18L1

Target: SS18L1 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 1 (SS18L1))

Alternative Name: SS18L1

Background:

Synonyms: Calcium-responsive transactivator|SS18-like protein 1|SYT homolog 1|SS18L1|CREST|KIAA0693

Background: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein(CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP(By similarity).

Molecular Weight: 50 kDa

Gene ID: 26039

UniProt: O75177