TBC1D5 antibody

Catalog No. ABIN7119805

This Rabbit Polyclonal antibody specifically detects TBC1D5 in WB, ELISA, IP and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TBC1D5 antibody (ABIN7119805)

Target: TBC1D5 (TBC1 Domain Family, Member 5 (TBC1D5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (IHC)

Product Details anti-TBC1D5 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: TBC1 domain family, member 5

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2400, IP: 1:200-1:1000 , IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for TBC1D5

Target: TBC1D5 (TBC1 Domain Family, Member 5 (TBC1D5))

Alternative Name: TBC1D5

Background: Synonyms:KIAA0210 Background:May act as a GTPase-activating protein(GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol, at least retromer displacement seems to require its catalytic activity(PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN), the function seems to require its catalytic activity. Involved in regulation of autophagy(PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes(PubMed:24603492).

Molecular Weight: 89 kDa

Gene ID: 9779

UniProt: Q92609