TTI1 antibody

Catalog No. ABIN7119826

This Rabbit Polyclonal antibody specifically detects TTI1 in ELISA, WB and IP. It exhibits reactivity toward Human.

Quick Overview for TTI1 antibody (ABIN7119826)

Target: TTI1 (TELO2 Interacting Protein 1 (TTI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTI1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-TTI1 Antibody

Purpose: TTI1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: KIAA0406

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IP: 1:500-1:5000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TTI1

Target: TTI1 (TELO2 Interacting Protein 1 (TTI1))

Alternative Name: TTI1

Background:

Synonyms: TELO2-interacting protein 1 homolog|Protein SMG10|TTI1|KIAA0406|SMG10

Background: Regulator of the DNA damage response(DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase(PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation(IR), ultraviolet(UV) and mitomycin C(MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.

Molecular Weight: 122 kDa

Gene ID: 9675

UniProt: O43156