TRAIP antibody (AA 1-204)

Catalog No. ABIN7120031

The Rabbit Polyclonal anti-TRAIP antibody has been validated for ELISA, IHC, WB and IF. It is suitable to detect TRAIP in samples from Human and Mouse.

Quick Overview for TRAIP antibody (AA 1-204) (ABIN7120031)

Target: TRAIP (TRAF Interacting Protein (TRAIP))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAIP antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-TRAIP Antibody

Binding Specificity: AA 1-204

Purpose: TRAIP antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-204aa

Immunogen: TRAF interacting protein

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TRAIP

Target: TRAIP (TRAF Interacting Protein (TRAIP))

Alternative Name: TRAIP

Background:

Synonyms: E3 ubiquitin-protein ligase TRAIP|RING finger protein 206|TRAF-interacting protein|TRAIP|RNF206|TRIP

Background: E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4-and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation(By similarity)(PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase(PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity(PubMed:24553286). The function in translesion synthesis is controversial(PubMed:26595769).

Molecular Weight: 53 kDa

Gene ID: 10293

UniProt: Q9BWF2