Uromodulin antibody (AA 300-587)

Catalog No. ABIN7120648

This Rabbit Polyclonal antibody specifically detects Uromodulin in WB, IHC, IP and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Uromodulin antibody (AA 300-587) (ABIN7120648)

Target: Uromodulin (UMOD)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Uromodulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA

Product Details anti-Uromodulin Antibody

Binding Specificity: AA 300-587

Purpose: UMOD antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 300-587aa

Immunogen: uromodulin

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IHC: 1:20-1:500, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Uromodulin

Target: Uromodulin (UMOD)

Alternative Name: UMOD

Background:

Synonyms: Uromodulin|Tamm-Horsfall urinary glycoprotein (THP)|Uromodulin, secreted form|UMOD

Background: Uromodulin, also known as THP(Tamm-Horsfall glycoprotein), is the most abundant protein excreted in the urine under physiological conditions. Uromodulin is synthesized by kidney and localizes in cells lining the ascending limb of Henle and distal convoluted tubule. Uromodulin has been linked to water/electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrated that it has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases.(PMID: 21654721)

Molecular Weight: 55-70 kDa

UniProt: P07911