Recombinant S100P antibody (C-Term)

Catalog No. ABIN7126919

This anti-S100P antibody is a Rabbit Monoclonal antibody detecting S100P in IHC (f). Suitable for Human.

Quick Overview for Recombinant S100P antibody (C-Term) (ABIN7126919)

Target: S100P (S100 Calcium Binding Protein P (S100P))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This S100P antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Product Details anti-S100P Antibody

Binding Specificity: C-Term

Specificity: S100P is a 95-amino-acid protein and a member of the S100 family. S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca2+ ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D.S100P highly expressed in human placenta, gastrointestinal tract, and esophageal mucosa, but always negative in pancreas and liver. Overexpression of S100P has been detected in several cancers such as breast, colon, prostate, pancreatic and lung carcinomas, and the protein has been functionally implicated in carcinogenic processes. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment corresponding to C-terminal of human S100P protein

Isotype: IgG

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Human pancreatic adenocarcinoma, placenta or spleen tissue.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for S100P

Target: S100P (S100 Calcium Binding Protein P (S100P))

Alternative Name: S100P

Background: Migration inducing gene 9 (MIG9), S100E, S100 calcium binding protein P,S100P
Cellular localisation: Nucleus. Cytoplasm. Colocalizes with S100PBP in the nucleus.

Molecular Weight: 10kDa

Gene ID: 6286, 2962

UniProt: P25815

Pathways: Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades, S100 Proteins