SFTPD antibody (AA 241-336)

Catalog No. ABIN7126935

This Mouse Monoclonal antibody specifically detects SFTPD in IHC (f). It exhibits reactivity toward Human.

Quick Overview for SFTPD antibody (AA 241-336) (ABIN7126935)

Target: SFTPD (Surfactant Protein D (SFTPD))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SFTPD antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Product Details anti-SFTPD Antibody

Binding Specificity: AA 241-336

Specificity: Pulmonary surfactant is primarily responsible for lowering the surface tension at the air-liquid interface in the alveoli, a process that is essential for normal respiration. Pulmonary surfactant is a mixture of phospholipids and proteins, including four distinct surfactant-associated proteins (SPs), SP-A, SP-B, SP-C, SP-D. SP-B and SP-C are predominantly hydrophobic proteins that associate with lipids to promote the absorption of surfactant phospholipids and to reduce the surface tension in the alveoli. SP-A and SP-D are large multimeric proteins belonging to the family of calcium-dependent lectins, designated Collectins, which contribute to the innate immune system. Both SP-A and SP-D have been shown to protect against microbial challenge through binding to the lipid components of the bacterial cell wall and facilitating the rapid removal of microbials.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant fragment (around aa241-336) of human SFTPD protein (exact sequence is proprietary)

Isotype: IgG2

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Positive_Control: Epithelial cells of the lung, skin, small intestine or bladder.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for SFTPD

Target: SFTPD (Surfactant Protein D (SFTPD))

Alternative Name: SFTPD

Background: COLEC7, Collectin-7, Lung surfactant protein D, PSP-D Surfactant protein D, PSPD, Pulmonary surfactant associated protein PSP-D, SFTP 4, SFTP4, SFTPD, SP-D, Surfactant associated protein pulmonary 4,Pulmonary Surfactant-Associated Protein D (SFTPD)
Cellular localisation: Secreted.

Molecular Weight: 43kDa

Gene ID: 6441, 253495

UniProt: P35247