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Recombinant CD3 epsilon antibody (AA 100-200)

This Rabbit Monoclonal antibody specifically detects CD3 epsilon in IHC (f). It exhibits reactivity toward Human.
Catalog No. ABIN7127130

Quick Overview for Recombinant CD3 epsilon antibody (AA 100-200) (ABIN7127130)

Target

See all CD3 epsilon (CD3E) Antibodies
CD3 epsilon (CD3E)

Antibody Type

Recombinant Antibody

Reactivity

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Human

Host

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Rabbit

Clonality

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Monoclonal

Conjugate

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This CD3 epsilon antibody is un-conjugated

Application

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Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
  • Binding Specificity

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    AA 100-200

    Specificity

    Cluster of differentiation 3 (CD3) is a multimeric protein complex, known historically as the T3 complex, and is composed of four distinct polypeptide chains, epsilon ( ), gamma (i³), delta ( L) and zeta ( A•), that assemble and function as three pairs of dimers ( i³, L, A• A•). The CD3 complex serves as a T cell co-receptor that associates noncovalently with the T cell receptor (TCR).CD3 antigen appearance at all stages of T cell development, and makes it an ideal T cell marker for both the detection of normal T cells and T cell neoplasms (lymphomas and leukemias).

    Cross-Reactivity (Details)

    Human.

    Purification

    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

    Immunogen

    Recombinant human CD3e fragment (around aa100-200) (exact sequence is proprietary)

    Isotype

    IgG
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Positive_Control: Human tonsil, spleen or lymph node. Human peripheral blood or Jurkat cells.

    Restrictions

    For Research Use only
  • Concentration

    1.0 mg/mL

    Buffer

    Prepared in 10 mM PBS, WITHOUT BSA and Azide.

    Preservative

    Azide free

    Storage

    -20 °C,-80 °C

    Storage Comment

    Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

    Expiry Date

    24 months
  • Target

    CD3 epsilon (CD3E)

    Alternative Name

    CD3E

    Background

    CD3 epsilon, CD3 TCR complex, T cell antigen receptor complex epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, T3E, TCRE, TiT3 complex,CD3e (T-Cell Marker)
    Cellular localisation: Cell Surface. Cytoplasm.

    Molecular Weight

    20-25kDa

    Gene ID

    916, 3003

    UniProt

    P07766

    Pathways

    TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
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