SPATA13 antibody

Catalog No. ABIN7131154

This anti-SPATA13 antibody is a Rabbit Polyclonal antibody detecting SPATA13 in WB, ELISA and IHC. Suitable for Human.

Quick Overview for SPATA13 antibody (ABIN7131154)

Target: SPATA13 (Spermatogenesis Associated 13 (SPATA13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPATA13 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SPATA13 Antibody

Cross-Reactivity: Human, Mouse

Purification: Antigen affinity purification

Immunogen: Fusion protein of Human SPATA13

Isotype: IgG

Application Details

Application Notes: ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SPATA13

Target: SPATA13 (Spermatogenesis Associated 13 (SPATA13))

Alternative Name: SPATA13

Background:

Background: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.

Aliases: APC-stimulated guanine nucleotide exchange factor 2 antibody, ARHGEF29 antibody, Asef2 antibody, FLJ31208 antibody, RP11-307N16.3 antibody, Spata13 antibody, Spermatogenesis-associated protein 13 antibody, SPT13_HUMAN antibody

UniProt: Q96N96