HADHB antibody (AA 231-330) (Cy7)

Catalog No. ABIN709157

Product Details anti-HADHB Antibody (Cy7)

Target: HADHB (Hydroxyacyl-CoA Dehydrogenase/3-Ketoacyl-CoA Thiolase/enoyl-CoA Hydratase (Trifunctional Protein), beta Subunit (HADHB))

Binding Specificity: AA 231-330

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HADHB antibody is conjugated to Cy7

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HADHB

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HADHB

Target: HADHB (Hydroxyacyl-CoA Dehydrogenase/3-Ketoacyl-CoA Thiolase/enoyl-CoA Hydratase (Trifunctional Protein), beta Subunit (HADHB))

Alternative Name: HADHB (HADHB Products)

Background:

Synonyms: 2 enoyl Coenzyme A (CoA) hydratase beta subunit, 3 ketoacyl Coenzyme A (CoA) thiolase of mitochondrial trifunctional protein beta subunit, 3 ketoacyl Coenzyme A thiolase, 3 ketoacyl Coenzyme A thiolase of mitochondrial trifunctional protein beta subunit, Acetyl CoA acyltransferase, Beta ketothiolase, ECHB, HADH, Hydroxyacyl Coenzyme A (CoA) dehydrogenase beta subunit, Hydroxyacyl Coenzyme A dehydrogenase, Hydroxyacyl Coenzyme A dehydrogenase beta subunit, Hydroxyacyl Coenzyme A dehydrogenase/3 ketoacyl Coenzyme A thiolase/enoyl Coenzyme A hydratase (trifunctional protein) beta subunit, Mitochondrial trifunctional enzyme beta subunit, Mitochondrial trifunctional protein beta subunit, MTPB, TP beta. TPbeta, Trifunctional enzyme subunit beta, Trifunctional enzyme subunit beta mitochondrial, Trifunctional protein, ECHB_HUMAN.

Background: The HADHB gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. Mutations in this gene result in trifunctional protein deficiency. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Alternatively spliced transcript variants have been found, however, their full-length nature is not known.

Gene ID: 151556

UniProt: P55084

Pathways: Monocarboxylic Acid Catabolic Process