Ceramide Synthase 2 antibody (AA 201-300) (HRP)

Catalog No. ABIN709340

The Rabbit Polyclonal anti-Ceramide Synthase 2 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect Ceramide Synthase 2 in samples from Mouse and Rat.

Quick Overview for Ceramide Synthase 2 antibody (AA 201-300) (HRP) (ABIN709340)

Target: Ceramide Synthase 2 (CERS2)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ceramide Synthase 2 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Ceramide Synthase 2 Antibody (HRP)

Binding Specificity: AA 201-300

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Ceramide synthase 2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Ceramide Synthase 2

Target: Ceramide Synthase 2 (CERS2)

Alternative Name: Ceramide synthase 2

Background:

Synonyms: L3, LASS2, SP260, TMSG1, Ceramide synthase 2, CerS2, LAG1 longevity assurance homolog 2, Tumor metastasis-suppressor gene 1 protein

Background: LASS2 (LAG1 homolog, ceramide synthase 2) has sequence similarity to yeast longevity assurance gene 1. It is thought to be involved in sphingolipid synthesis. Expression of LASS2 is transiently increased during the period of active myelination and is specifically localized to white matter tracts of the brain, including the Schwann cells of sciatic nerves suggesting that LASS2 is important for the synthesis of dihydroceramide used for synthesis of myelin sphingolipids. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.

Gene ID: 29956

UniProt: Q96G23