Lamin B Receptor antibody (AA 1-100)

Catalog No. ABIN709391

The Rabbit Polyclonal anti-Lamin B Receptor antibody has been validated for WB, ELISA and FACS. It is suitable to detect Lamin B Receptor in samples from Human and Mouse.

Quick Overview for Lamin B Receptor antibody (AA 1-100) (ABIN709391)

Target: Lamin B Receptor (LBR)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin B Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Lamin B Receptor Antibody

Binding Specificity: AA 1-100

Specificity: The immunogen for this product has partial sequence similarity to SEPT8 and SEPT2

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Lamin B Receptor

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Lamin B Receptor

Target: Lamin B Receptor (LBR)

Alternative Name: Lamin B Receptor

Background:

Synonyms: PHA, LMN2R, TDRD18, DHCR14B, Lamin-B receptor, Integral nuclear envelope inner membrane protein, LBR

Background: Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization. Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. The cleavage of lamins results in nuclear disregulation and cell death.

Gene ID: 3930

UniProt: Q14739