CRY1 antibody

Catalog No. ABIN7138290

The Rabbit Polyclonal anti-CRY1 antibody has been validated for WB and ELISA. It is suitable to detect CRY1 in samples from Human.

Quick Overview for CRY1 antibody (ABIN7138290)

Target: CRY1 (Cryptochrome 1 (Photolyase-Like) (CRY1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRY1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CRY1 Antibody

Purpose: CRY1 Antibody

Cross-Reactivity: Mouse

Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Human CRY1.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CRY1

Target: CRY1 (Cryptochrome 1 (Photolyase-Like) (CRY1))

Alternative Name: CRY1

Background:

Background:

Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45.
Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8.
Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.

Aliases: Cry1 antibody, CRY1_HUMAN antibody, Cryptochrome 1 (photolyase like) antibody, Cryptochrome 1 antibody, Cryptochrome-1 antibody, PHLL1 antibody, Photolyase 1 antibody, Photolyase-like antibody

UniProt: Q16526

Pathways: Response to Water Deprivation, Proton Transport