beta Arrestin 1 antibody (pSer412)

Catalog No. ABIN7138607

This Rabbit Polyclonal antibody specifically detects beta Arrestin 1 in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for beta Arrestin 1 antibody (pSer412) (ABIN7138607)

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta Arrestin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-beta Arrestin 1 Antibody

Binding Specificity: pSer412

Cross-Reactivity: Human

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 412 (T-G-S(p)-P-Q) derived from Human Arrestin 1.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for beta Arrestin 1

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Alternative Name: ARRB1

Background:

Background:

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein, the binding appears to require additional receptor determinants exposed only in the active receptor conformation.

Greg Buchanan. AACR Meeting Abstracts, Apr 2006, 2006: 430.
D. Alex Groarke. Mol. Pharmacol., Feb 2001, 59: 375.
Karen McConalogue. Mol. Biol. Cell, Aug 1998, 9: 2305.
Maria Stella Lombardi. Stroke, Apr 2004, 35: 981 - 986.

Aliases: ARB1 antibody, ARR1 antibody, ARRB1 antibody, ARRB1_HUMAN antibody, Arrestin 2 antibody, Arrestin beta 1 antibody, Arrestin beta-1 antibody, Beta-arrestin-1 antibody

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction