Cadherin 5 antibody (pTyr731)

Catalog No. ABIN7139104

This anti-Cadherin 5 antibody is a Rabbit Polyclonal antibody detecting Cadherin 5 in WB and ELISA. Suitable for Human.

Quick Overview for Cadherin 5 antibody (pTyr731) (ABIN7139104)

Target: Cadherin 5 (CDH5)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Cadherin 5 Antibody

Binding Specificity: pTyr731

Cross-Reactivity: Human, Mouse

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Tyrosine731 (H-I-Y(p)-G-Y) derived from Human VE-Cadherin.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Cadherin 5

Target: Cadherin 5 (CDH5)

Alternative Name: CDH5

Background:

Background:

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen.

Wessel F, et al. (2014) Nat Immunol 15, 223-30
Sawada J, et al. (2012) Cancer Cell 22, 235-49
Turowski P, et al. (2008) J Cell Sci 121, 29-37

Aliases: 7B 4 antibody, 7B4 antibody, 7B4 antigen antibody, CADH5_HUMAN antibody, Cadherin 5 antibody, Cadherin 5 type 2 antibody, Cadherin 5, type 2 (vascular endothelium) antibody, Cadherin 5, type 2, VE cadherin (vascular epithelium) antibody, cadherin, vascular endothelial antibody, cadherin, vascular endothelial, 1 antibody, Cadherin-5 antibody, Cadherin5 antibody, CD 144 antibody, CD144 antibody, CD144 antigen antibody, CDH 5 antibody, CDH5 antibody, CDH5 protein antibody, Endothelial specific cadherin antibody, FLJ17376 antibody, OTTHUMP00000174777 antibody, Vascular endothelial cadherin antibody, Vascular epithelium cadherin antibody, VE Cad antibody, VE-cadherin antibody, VEC antibody

UniProt: P33151

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2