ULK1 antibody (AA 11-312) (Biotin)

Catalog No. ABIN7140917

This Rabbit Polyclonal antibody specifically detects ULK1 in ELISA. It exhibits reactivity toward Candida sp..

Quick Overview for ULK1 antibody (AA 11-312) (Biotin) (ABIN7140917)

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Reactivity: Candida sp.

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULK1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-ULK1 Antibody (Biotin)

Binding Specificity: AA 11-312

Cross-Reactivity: Candida sp.

Purification: >95%, Protein G purified

Immunogen: Recombinant Candida glabrata Serine/threonine-protein kinase ATG1 protein (11-312AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ULK1

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Alternative Name: ATG1

Background:

Background: Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9.

Aliases: ATG1 antibody, CAGL0L06006g antibody, Serine/threonine-protein kinase ATG1 antibody, EC 2.7.11.1 antibody, Autophagy-related protein 1 antibody

UniProt: Q6FL58

Pathways: Regulation of Cell Size, Autophagy