MICAL1 antibody (AA 806-1067) (Biotin)

Catalog No. ABIN7141991

This Rabbit Polyclonal antibody specifically detects MICAL1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for MICAL1 antibody (AA 806-1067) (Biotin) (ABIN7141991)

Target: MICAL1 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 1 (MICAL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MICAL1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-MICAL1 Antibody (Biotin)

Binding Specificity: AA 806-1067

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human [F-actin]-methionine sulfoxide oxidase MICAL1 protein (806-1067AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MICAL1

Target: MICAL1 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 1 (MICAL1))

Alternative Name: MICAL1

Background:

Background: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L, acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of sectrory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking.

Aliases: CasL interacting molecule antibody, DKFZp434B1517 antibody, FLJ11937 antibody, FLJ21739 antibody, MICA1_HUMAN antibody, MICAL 1 antibody, MICAL antibody, MICAL1 antibody, microtubule associated monoxygenase, calponin and LIM domain containing 1 antibody, Molecule interacting with CasL protein 1 antibody, NEDD9 interacting protein with calponin homology and LIM domains antibody, NEDD9-interacting protein with calponin homology and LIM domains antibody, NICAL antibody, OTTHUMP00000016969 antibody

UniProt: Q8TDZ2