RNASEL antibody (AA 330-741)

Catalog No. ABIN7142130

The Rabbit Polyclonal anti-RNASEL antibody has been validated for ELISA and IHC. It is suitable to detect RNASEL in samples from Human.

Quick Overview for RNASEL antibody (AA 330-741) (ABIN7142130)

Target: RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNASEL antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-RNASEL Antibody

Binding Specificity: AA 330-741

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 2-5A-dependent ribonuclease protein (330-741AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNASEL

Target: RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL))

Alternative Name: RNASEL

Background:

Background: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.

Aliases: 2 5A dependent ribonuclease antibody, 2 5A dependent RNase antibody, 2' 5' oligoisoadenylate synthetase dependent antibody, 2-5A-dependent ribonuclease antibody, 2-5A-dependent RNase antibody, DKFZp781D08126 antibody, Interferon induced 2 5A dependent RNase antibody, MGC104972 antibody, MGC133329 antibody, PRCA 1 antibody, PRCA1 antibody, Ribonuclease 4 antibody, Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) antibody, Ribonuclease L antibody, Ribonuclease4 antibody, RibonucleaseL antibody, RN5A_HUMAN antibody, RNase L antibody, Rnasel antibody, RNS 4 antibody, RNS4 antibody

UniProt: Q05823

Pathways: Hepatitis C