PSMC4 antibody (Regulatory Subunit 6B)

Catalog No. ABIN7142234

Product Details anti-PSMC4 Antibody

Target: PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))

Binding Specificity: AA 112-181, Regulatory Subunit 6B

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human 26S proteasome regulatory subunit 6B protein (112-181AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PSMC4

Target: PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))

Alternative Name: PSMC4 (PSMC4 Products)

Background:

Background: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Aliases: 26S protease regulatory subunit 6B antibody, 26S proteasome AAA ATPase subunit RPT3 antibody, 26S proteasome AAA-ATPase subunit RPT3 antibody, MB67 interacting protein antibody, MB67-interacting protein antibody, MIP224 antibody, Protease 26S subunit 6 antibody, Proteasome (prosome macropain) 26S subunit ATPase 4 antibody, Proteasome 19S S6 antibody, Proteasome 26S subunit ATPase 4 antibody, Proteasome 26S subunit, ATPase, 4 antibody, PRS6B_HUMAN antibody, PSMC4 antibody, RPT3 antibody, S6 antibody, Tat binding protein 7 antibody, TAT-binding protein 7 antibody, TBP 7 antibody, TBP-7 antibody

UniProt: P43686

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway