Adhesion G Protein-Coupled Receptor G1 (ADGRG1) (AA 26-216) antibody (Biotin)

Catalog No. ABIN7143400

This anti- antibody is a Rabbit Polyclonal antibody detecting in ELISA. Suitable for Human.

Quick Overview for Adhesion G Protein-Coupled Receptor G1 (ADGRG1) (AA 26-216) antibody (Biotin) (ABIN7143400)

Target: Adhesion G Protein-Coupled Receptor G1 (ADGRG1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: ELISA

Product Details

Binding Specificity: AA 26-216

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Adhesion G-protein coupled receptor G1 protein (26-216AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Adhesion G Protein-Coupled Receptor G1 (ADGRG1)

Alternative Name: ADGRG1

Background:

Background: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity).

Aliases: 7 transmembrane protein with no EGF like N terminal domains 1 antibody, BFPP antibody, DKFZp781L1398 antibody, EGF TM7 like antibody, G protein coupled receptor 56 antibody, G-protein coupled receptor 56 antibody, GPR 56 antibody, Gpr56 antibody, GPR56_HUMAN antibody, Polymicrogyria bilateral frontoparietal antibody, Protein TM7XN1 antibody, TM7LN4 antibody, TM7XN1 antibody, TM7XN1 protein antibody

UniProt: Q9Y653