FE65 antibody (AA 361-710)

Catalog No. ABIN7144040

This Rabbit Polyclonal antibody specifically detects FE65 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for FE65 antibody (AA 361-710) (ABIN7144040)

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FE65 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-FE65 Antibody

Binding Specificity: AA 361-710

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Amyloid beta A4 precursor protein-binding family B member 1 protein (361-710AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FE65

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Alternative Name: APBB1

Background:

Background: Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on \\\'Tyr-142\\\' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).

Aliases: Adaptor protein FE65a2 antibody, Amyloid beta (A4) precursor protein binding family B member 1 antibody, Amyloid beta A4 precursor protein binding family B antibody, Amyloid beta A4 precursor protein binding family B member 1 antibody, Amyloid beta A4 precursor protein-binding family B member 1 antibody, Amyloid beta precursor protein binding family B member 1 antibody, APBB 1 antibody, APBB1 antibody, APBB1_HUMAN antibody, FE 65 antibody, Fe65 protein antibody, Protein Fe65 antibody, RIR antibody, stat like protein antibody

UniProt: O00213

Pathways: Positive Regulation of Response to DNA Damage Stimulus