Asporin antibody (AA 33-380) (Biotin)

Catalog No. ABIN7144762

This anti-Asporin antibody is a Rabbit Polyclonal antibody detecting Asporin in ELISA. Suitable for Human.

Quick Overview for Asporin antibody (AA 33-380) (Biotin) (ABIN7144762)

Target: Asporin (ASPN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Asporin antibody is conjugated to Biotin

Application: ELISA

Product Details anti-Asporin Antibody (Biotin)

Binding Specificity: AA 33-380

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Asporin protein (33-380AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Asporin

Target: Asporin (ASPN)

Alternative Name: ASPN

Background:

Background: Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.

Aliases: ASPN antibody, ASPN protein antibody, ASPN_HUMAN antibody, Asporin (LRR class 1) antibody, Asporin antibody, Asporin proteoglycan antibody, FLJ20129 antibody, LRR class 1 antibody, Periodontal ligament associated protein 1 antibody, Periodontal ligament-associated protein 1 antibody, PLAP 1 antibody, PLAP-1 antibody, PLAP1 antibody, SLRR 1C antibody, SLRR1C antibody, Small leucine rich protein 1C antibody

UniProt: Q9BXN1