KCNJ11 antibody (AA 172-390)

Catalog No. ABIN7145021

This Rabbit Polyclonal antibody specifically detects KCNJ11 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for KCNJ11 antibody (AA 172-390) (ABIN7145021)

Target: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNJ11 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-KCNJ11 Antibody

Binding Specificity: AA 172-390

Purpose: KCNJ11 Antibody

Cross-Reactivity: Mouse

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human ATP-sensitive inward rectifier potassium channel 11 protein (172-390AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KCNJ11

Target: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Alternative Name: KCNJ11

Background:

Background: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Aliases: KCNJ11 antibody, ATP-sensitive inward rectifier potassium channel 11 antibody, IKATP antibody, Inward rectifier K(+) channel Kir6.2 antibody, Potassium channel antibody, inwardly rectifying subfamily J member 11 antibody

UniProt: Q14654

Pathways: Negative Regulation of Hormone Secretion