CKAP5 antibody (AA 1802-2019)

Catalog No. ABIN7149368

This Rabbit Polyclonal antibody specifically detects CKAP5 in WB, ELISA, IF and IHC. It exhibits reactivity toward Human.

Quick Overview for CKAP5 antibody (AA 1802-2019) (ABIN7149368)

Target: CKAP5 (Cytoskeleton Associated Protein 5 (CKAP5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CKAP5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-CKAP5 Antibody

Binding Specificity: AA 1802-2019

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Cytoskeleton-associated protein 5 protein (1802-2019AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CKAP5

Target: CKAP5 (Cytoskeleton Associated Protein 5 (CKAP5))

Alternative Name: CKAP5

Background:

Background: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448).

Aliases: CKAP5 antibody, KIAA0097Cytoskeleton-associated protein 5 antibody, Colonic and hepatic tumor overexpressed gene protein antibody, Ch-TOG antibody

UniProt: Q14008

Pathways: M Phase