DACH1 antibody (AA 166-369) (HRP)

Catalog No. ABIN7149479

This Rabbit Polyclonal antibody specifically detects DACH1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for DACH1 antibody (AA 166-369) (HRP) (ABIN7149479)

Target: DACH1 (Dachshund 1 (DACH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DACH1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-DACH1 Antibody (HRP)

Binding Specificity: AA 166-369

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Dachshund homolog 1 protein (166-369AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DACH1

Target: DACH1 (Dachshund 1 (DACH1))

Alternative Name: DACH1

Background:

Background: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Aliases: DACH antibody, Dach1 antibody, DACH1_HUMAN antibody, Dachshund family transcription factor 1 antibody, dachshund homolog 1 (Drosophila) antibody, Dachshund homolog 1 antibody, Dachsund homolog 1 antibody, FLJ10138 antibody, OTTHUMP00000018494 antibody

UniProt: Q9UI36

Pathways: Feeding Behaviour