A Disintegrin and Metallopeptidase Domain 1a (ADAM1A) (AA 214-504) antibody (HRP)

Catalog No. ABIN7150037

This Rabbit Polyclonal antibody specifically detects in ELISA. It exhibits reactivity toward Human.

Quick Overview for A Disintegrin and Metallopeptidase Domain 1a (ADAM1A) (AA 214-504) antibody (HRP) (ABIN7150037)

Target: A Disintegrin and Metallopeptidase Domain 1a (ADAM1A)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: ELISA

Product Details

Binding Specificity: AA 214-504

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Disintegrin and metalloproteinase domain-containing protein 10 protein (214-504AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: A Disintegrin and Metallopeptidase Domain 1a (ADAM1A)

Alternative Name: ADAM1

Background:

Background: Cleaves the membrane-bound precursor of TNF-alpha at \'76-Ala-|-Val-77\' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Aliases: A disintegrin and metalloprotease domain 10 antibody, A disintegrin and metalloproteinase domain 10 antibody, AD 10 antibody, AD10 antibody, AD18 antibody, ADA10_HUMAN antibody, ADAM 10 antibody, ADAM metallopeptidase domain 10 antibody, ADAM10 antibody, CD 156c antibody, CD156c antibody, CD156c antigen antibody, CDw156 antibody, disintegrin and metalloproteinase domain containing protein 10 antibody, Disintegrin and metalloproteinase domain-containing protein 10 antibody, HsT 18717 antibody, HsT18717 antibody, Kuz antibody, Kuzbanian antibody, Kuzbanian protein homolog antibody, Kuzbanian, Drosophila, homolog of antibody, MADM antibody, Mammalian disintegrin metalloprotease antibody, Mammalian disintegrin-metalloprotease antibody, RAK antibody

UniProt: O14672