MCM8 antibody (AA 1-67) (Biotin)

Catalog No. ABIN7150182

The Rabbit Polyclonal anti-MCM8 antibody has been validated for ELISA. It is suitable to detect MCM8 in samples from Human.

Quick Overview for MCM8 antibody (AA 1-67) (Biotin) (ABIN7150182)

Target: MCM8 (Minichromosome Maintenance Deficient 8 (MCM8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM8 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-MCM8 Antibody (Biotin)

Binding Specificity: AA 1-67

Purpose: MCM8 Antibody, Biotin conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human DNA helicase MCM8 protein (1-67AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MCM8

Target: MCM8 (Minichromosome Maintenance Deficient 8 (MCM8))

Alternative Name: MCM8

Background:

Background: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.

Aliases: C20orf154 antibody, dJ967N21.5 antibody, DNA helicase MCM8 antibody, DNA replication licensing factor MCM8 antibody, MCM8 antibody, MCM8_HUMAN antibody, MGC119522 antibody, MGC119523 antibody, MGC12866 antibody, MGC4816 antibody, Minichromosome maintenance 8 antibody, Minichromosome maintenance complex component 8 antibody, REC antibody

UniProt: Q9UJA3

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA