RNF128 antibody (AA 229-400) (Biotin)

Catalog No. ABIN7151139

The Rabbit Polyclonal anti-RNF128 antibody has been validated for ELISA. It is suitable to detect RNF128 in samples from Human.

Quick Overview for RNF128 antibody (AA 229-400) (Biotin) (ABIN7151139)

Target: RNF128 (Ring Finger Protein 128 (RNF128))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF128 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-RNF128 Antibody (Biotin)

Binding Specificity: AA 229-400

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF128 protein (229-400AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNF128

Target: RNF128 (Ring Finger Protein 128 (RNF128))

Alternative Name: RNF128

Background:

Background: E3 ubiquitin-protein ligase that catalyzes \'Lys-48\'- and \'Lys-63\'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with \'Lys-48\' linkages and COR1A with \'Lys-63\' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm, sensitizes ectoderm to respond to neural-inducing signals.

Aliases: E3 ubiquitin protein ligase RNF128 antibody, E3 ubiquitin-protein ligase RNF128 antibody, FLJ23516 antibody, Gene related to anergy in lymphocytes protein antibody, GRAIL antibody, RING finger protein 128 antibody, RN128_HUMAN antibody, RNF128 antibody

UniProt: Q8TEB7