EHD3 antibody (AA 269-498) (HRP)

Catalog No. ABIN7151464

This anti-EHD3 antibody is a Rabbit Polyclonal antibody detecting EHD3 in ELISA. Suitable for Human.

Quick Overview for EHD3 antibody (AA 269-498) (HRP) (ABIN7151464)

Target: EHD3 (EH-Domain Containing 3 (EHD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EHD3 antibody is conjugated to HRP

Application: ELISA

Product Details anti-EHD3 Antibody (HRP)

Binding Specificity: AA 269-498

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human EH domain-containing protein 3 protein (269-498AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EHD3

Target: EHD3 (EH-Domain Containing 3 (EHD3))

Alternative Name: EHD3

Background:

Background: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte exitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis, possibly sharing redundant functions with EHD1 (PubMed:25686250).

Aliases: EHD3 antibody, EHD2 antibody, PAST3EH domain-containing protein 3 antibody, PAST homolog 3 antibody

UniProt: Q9NZN3