DICER1 antibody (AA 1721-1922) (HRP)

Catalog No. ABIN7151710

Product Details anti-DICER1 Antibody (HRP)

Target: DICER1 (Dicer 1, Ribonuclease Type III (DICER1))

Binding Specificity: AA 1721-1922

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DICER1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Endoribonuclease Dicer protein (1721-1922AA )

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for DICER1

Target: DICER1 (Dicer 1, Ribonuclease Type III (DICER1))

Alternative Name: DICER1 (DICER1 Products)

Background:

Background: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3\' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

Aliases: DCR antibody, DCR1 antibody, Dicer 1 ribonuclease III antibody, Dicer 1 ribonuclease type III antibody, Dicer antibody, DICER_HUMAN antibody, DICER1 antibody, Double-strand-specific ribonuclease antibody, Endoribonuclease Dicer antibody, Helicase MOI antibody, Helicase with RNase motif antibody, HERNA antibody, KIAA0928 antibody, MNG1 antibody, RMSE2 antibody

UniProt: Q9UPY3

Pathways: Regulatory RNA Pathways, Stem Cell Maintenance, Ribonucleoprotein Complex Subunit Organization