PIK3R1 antibody (AA 15-180) (FITC)

Catalog No. ABIN7154496

The Rabbit Polyclonal anti-PIK3R1 antibody has been validated for . It is suitable to detect PIK3R1 in samples from Human.

Quick Overview for PIK3R1 antibody (AA 15-180) (FITC) (ABIN7154496)

Target: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIK3R1 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-PIK3R1 Antibody (FITC)

Binding Specificity: AA 15-180

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Growth factor receptor-bound protein 10 protein (15-180AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIK3R1

Target: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Alternative Name: GRB1

Background:

Background: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Aliases: grb 10 antibody, GRB IR antibody, grb-10 antibody, GRB10 adapter protein antibody, GRB10 adaptor protein antibody, GRB10 antibody, GRB10_HUMAN antibody, GRBIR antibody, Growth factor receptor bound protein 10 antibody, Growth factor receptor-bound protein 10 antibody, Insulin receptor binding protein antibody, Insulin receptor binding protein GRB IR antibody, Insulin receptor-binding protein Grb-IR antibody, IRBP antibody, KIAA0207 antibody, Maternally expressed gene 1 antibody, MEG1 antibody, RSS antibody

UniProt: Q13322

Pathways: TCR Signaling, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effect