HPSE antibody (AA 263-523) (HRP)

Catalog No. ABIN7155025

This anti-HPSE antibody is a Rabbit Polyclonal antibody detecting HPSE in ELISA. Suitable for Human.

Quick Overview for HPSE antibody (AA 263-523) (HRP) (ABIN7155025)

Target: HPSE (Heparanase (HPSE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HPSE antibody is conjugated to HRP

Application: ELISA

Product Details anti-HPSE Antibody (HRP)

Binding Specificity: AA 263-523

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Heparanase protein (263-523AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HPSE

Target: HPSE (Heparanase (HPSE))

Alternative Name: HPSE

Background:

Background: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.

Aliases: Endo glucoronidase antibody, Endo-glucoronidase antibody, HEP antibody, Heparanase 50 kDa subunit antibody, Heparanase antibody, Heparanase-1 antibody, Heparanase1 antibody, Hpa 1 antibody, HPA antibody, Hpa1 antibody, HPR 1 antibody, HPR1 antibody, HPSE 1 antibody, HPSE antibody, HPSE_HUMAN antibody, HPSE1 antibody, HSE 1 antibody, HSE1 antibody

UniProt: Q9Y251

Pathways: Glycosaminoglycan Metabolic Process