KAT5 antibody (AA 3-512) (Biotin)

Catalog No. ABIN7155275

This Rabbit Polyclonal antibody specifically detects KAT5 in ELISA. It exhibits reactivity toward Human.

Quick Overview for KAT5 antibody (AA 3-512) (Biotin) (ABIN7155275)

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KAT5 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-KAT5 Antibody (Biotin)

Binding Specificity: AA 3-512

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Histone acetyltransferase KAT5 protein (3-512AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Alternative Name: KAT5

Background:

Background: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

Aliases: 60 kDa Tat interactive protein antibody, 60 kDa Tat-interactive protein antibody, cPLA(2) interacting protein antibody, cPLA(2)-interacting protein antibody, cPLA2 antibody, cPLA2 interacting protein antibody, ESA1 antibody, Histone acetyltransferase HTATIP antibody, Histone acetyltransferase KAT5 antibody, HIV 1 Tat interactive protein antibody, HIV 1 Tat interactive protein, 60 kDa antibody, HIV-1 Tat interactive protein antibody, HTATIP antibody, HTATIP1 antibody, K(lysine) acetyltransferase 5 antibody, K-acetyltransferase 5 antibody, KAT5 antibody, KAT5_HUMAN antibody, Lysine acetyltransferase 5 antibody, PLIP antibody, Tat interacting protein, 60 kDa antibody, TIP antibody, Tip60 antibody

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway