ITPK1 antibody (AA 185-414)

Catalog No. ABIN7156320

The Rabbit Polyclonal anti-ITPK1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect ITPK1 in samples from Human.

Quick Overview for ITPK1 antibody (AA 185-414) (ABIN7156320)

Target: ITPK1 (Inositol-Tetrakisphosphate 1-Kinase (ITPK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITPK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-ITPK1 Antibody

Binding Specificity: AA 185-414

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Inositol-tetrakisphosphate 1-kinase protein (185-414AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ITPK1

Target: ITPK1 (Inositol-Tetrakisphosphate 1-Kinase (ITPK1))

Alternative Name: ITPK1

Background:

Background: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

Aliases: 3 antibody, 4)P(3) 5/6-kinase antibody, 4-trisphosphate 5/6-kinase antibody, Inositol 1 3 4 triphosphate 5/6 kinase antibody, Inositol 1 3 4 trisphosphate 5/6 kinase antibody, Inositol 1 antibody, Inositol tetrakisphosphate 1 kinase antibody, Inositol triphosphate 5/6 kinase antibody, Inositol-tetrakisphosphate 1-kinase antibody, Inositol-triphosphate 5/6-kinase antibody, Ins(1 3 4)P(3) 5/6 kinase antibody, Ins(1 antibody, ITPK 1 antibody, itpk1 antibody, ITPK1_HUMAN antibody, ITRPK 1 antibody, ITRPK1 antibody

UniProt: Q13572