IFIT2 antibody (AA 130-265)

Catalog No. ABIN7156667

This Rabbit Polyclonal antibody specifically detects IFIT2 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for IFIT2 antibody (AA 130-265) (ABIN7156667)

Target: IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIT2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-IFIT2 Antibody

Binding Specificity: AA 130-265

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Interferon-induced protein with tetratricopeptide repeats 2 protein (130-265AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IFIT2

Target: IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2))

Alternative Name: IFIT2

Background:

Background: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2\\\'-O-methylation of the 5\\\' cap. The ribose 2\\\'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2\\\'-O-methylase for their mRNAs or by stealing host cap containing the 2\\\'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5\\\' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

Aliases: CIG-42 antibody, cig42 antibody, G10P2 antibody, GARG 39 antibody, Glucocorticoid attenuated response gene 39 antibody, IFI 54 antibody, IFI 54K antibody, IFI-54K antibody, IFI54 antibody, IFIT 2 antibody, IFIT-2 antibody, IFIT2 antibody, IFIT2_HUMAN antibody, Interferon induced 54 kDa protein antibody, Interferon induced protein 54 antibody, Interferon induced protein with tetratricopeptide repeats 2 antibody, Interferon, alpha inducible protein (MW 54kD) antibody, Interferon-induced 54 kDa protein antibody, Interferon-induced protein with tetratricopeptide repeats 2 antibody, ISG 54 K antibody, ISG 54K antibody, ISG-54 K antibody, ISG54 antibody

UniProt: P09913